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  1. ZYNRELEF | Dual-Acting Local Anesthetic

    ZYNRELEF is indicated in adults for instillation to produce postsurgical analgesia for up to 72 hours after soft tissue and orthopedic procedures including foot and ankle, and other procedures in which direct …

  2. ZYNRELEF is applied without a needle into the surgical site following final irrigation and suction and prior to suturing (2.1). − The recommended dose of ZYNRELEF is up to a maximum dose of 400 …

  3. ZYNRELEF | Dosing and Administration

    ZYNRELEF is a viscous solution administered as a single-dose needle-free instillation to directly coat the affected tissue within the surgical site after final irrigation and suction and prior to suturing.

  4. ZYNRELEF | A Foundation for Postoperative Pain Management

    ZYNRELEF is a synergistic combination of bupivacaine and low-dose meloxicam 1 As the first and only extended-release dual-acting local anesthetic, ZYNRELEF is uniquely designed to address the …

  5. Postoperative Pain Management in General Surgery | ZYNRELEF

    ZYNRELEF is indicated in adults for instillation to produce postsurgical analgesia for up to 72 hours after soft tissue and orthopedic procedures including foot and ankle, and other procedures in which direct …

  6. ZYNRELEF | FAQs

    When applying ZYNRELEF during a laparoscopic procedure, ZYNRELEF can be placed onto the fascia of the trocar and extraction sites. It should not be applied directly to the peritoneum.

  7. ZYNRELEF | Information for Anesthesiologists

    ZYNRELEF is indicated in adults for instillation to produce postsurgical analgesia for up to 72 hours after soft tissue and orthopedic procedures including foot and ankle, and other procedures in which direct …

  8. 72 Hours of Postoperative Pain Relief | ZYNRELEF - Heron

    ZYNRELEF patients experienced superior pain relief through 72 hours—when pain is most severe—compared to patients receiving the current standard of care, bupivacaine HCl solution, …

  9. Feb 24, 2021 · Heron conducted rigorous clinical trials of ZYNRELEF across multiple surgical models, beginning with the Phase 2a studies, which in addition to establishing safety and efficacy in a smaller …

  10. Meeting the Demands of Postsurgical Pain Relief | ZYNRELEF

    ZYNRELEF is indicated in adults for instillation to produce postsurgical analgesia for up to 72 hours after soft tissue and orthopedic procedures including foot and ankle, and other procedures in which direct …