The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

Again, for argument’s sake, if reverse transcription wasn’t a problem, mRNA would still fall at the final hurdle. As Offit explained: “Even if it were reversed transcribed to DNA, which it's ...

Most recently we have focused our studies on how the termination of mRNA transcription is altered by heat shock. In the past several years, several studies in mammalian cells revealed that Pol II ...

Genes rely on transcription factors to perform many essential functions in organs. Together, Soto-Gutiérrez and Fox have analyzed more than 400 failing livers donated by transplant patients.

The regulation of mRNA transcription plays a key role in relaying signals from the environment and during development into the gene expression program of a cell. During transcription initiation, a ...

The growing incidence of infectious diseases, cancer, and chronic illnesses has substantially increased the demand for ...

Unlocking the potential of mRNA technology is helping revolutionize medicine and biotechnology. Solid-phase in vitro transcription enables scalability and automation, helping make it a valuable tool ...

During pre-mRNA transcription by Pol II, the spliceosome catalyzes two transesterification reactions along the RNA molecule, cleaving it twice and covalently joining adjacent exons, effectively ...

Republican lawmakers and federal health officials alike are shunning messenger RNA, a basic building block of biology that proved its value during COVID, and that holds promise for combating the ...

Over the last several days, the safety and efficacy of messenger RNA, or mRNA, vaccines have come under intense scrutiny. On Tuesday, the U.S. Food and Drug Administration announced plans to limit ...

Plus, the Ntensify solution works with any mRNA construct, and it is processed through one-pot in vitro transcription with co-transcriptional capping and a redesigned single-step purification to ...

One of mRNA’s greatest advantages is the ability to rapidly iterate and optimize sequences, accelerating drug discovery and development. Advances in cell-free gene synthesis and in vitro transcription ...