Again, for argument’s sake, if reverse transcription wasn’t a problem, mRNA would still fall at the final hurdle. As Offit explained: “Even if it were reversed transcribed to DNA, which it's ...

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

The regulation of mRNA transcription plays a key role in relaying signals from the environment and during development into the gene expression program of a cell. During transcription initiation, a ...

Plus, the Ntensify solution works with any mRNA construct, and it is processed through one-pot in vitro transcription with co-transcriptional capping and a redesigned single-step purification to ...

One of mRNA’s greatest advantages is the ability to rapidly iterate and optimize sequences, accelerating drug discovery and development. Advances in cell-free gene synthesis and in vitro transcription ...

Unlocking the potential of mRNA technology is helping revolutionize medicine and biotechnology. Solid-phase in vitro transcription enables scalability and automation, helping make it a valuable tool ...

Genes rely on transcription factors to perform many essential functions in organs. Together, Soto-Gutiérrez and Fox have analyzed more than 400 failing livers donated by transplant patients.

During pre-mRNA transcription by Pol II, the spliceosome catalyzes two transesterification reactions along the RNA molecule, cleaving it twice and covalently joining adjacent exons, effectively ...

In this experiment, they ran the TFF at a capacity load of ∼19 g/m 2, less than 2.5 psi trans-membrane pressure, and feed flux of 300 L/m 2 /h (LMH), corresponding to a shear rate of 1594 s −1 ...