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Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...
While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and ...
Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...
Identifying miRNA-mRNA network in CAFs and MSCs can show novel regulatory mechanisms for developing more effective therapeutic strategies targeting both cancer cells and their supportive ...
From identifying miRNA many years ago to the recent impact of modified mRNA for the COVID-19 vaccine, the Nobel wins reflect decades of foundational work finally bearing fruit.
Model-guided design of microRNA-based gene circuits supports precise dosage of transgenic cargoes into diverse primary cells. Cell Systems, 2025; 101269 DOI: 10.1016/j.cels.2025.101269 ...
Additional mRNA regulatory factors identified by the study included heparan sulfate (HSPG), a glycoprotein on the cell surface, and vascular ATPase, which mediate mRNA uptake and endosomal escape ...
For example, they have characterized the transcriptome (mRNA, lncRNA, and miRNA) of aortas in an atherosclerosis mouse model, both during disease progression and after regression following treatment.
A network containing 34 circRNA-miRNA pairs and 194 miRNA-mRNA pairs was constructed. Cell proliferation and migration assays confirmed the role of hsa_circ_0001726 in promoting HCC progression ...
And so it could have been that this particular small RNA base-pairing to this mRNA of lin-14 gene and turning off production of the protein from lin-14 messenger RNA, that could be a peculiar ...
MicroRNA acts primarily at the post-transcriptional level, meaning it affects mRNA after it has been made from DNA.