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A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.
The sequence requirements for T. cruzi, T. brucei and Leishmania mRNA processing were initially investigated by comparing expressed sequence tags and/or cDNAs with genomic sequences (Benz et al. 2005, ...
We report a novel approach to a new class of bioengineered, monodispersed, self-assembling vault nanoparticles consisting of a protein shell exterior with a lipophilic core interior designed for drug ...
This valuable manuscript investigates the localisation of nutrient receptors in bloodstream stage trypanosomes, with implications for both nutrient uptake and immune evasion. Results after direct ...
The relative synonymous codon usage (RSCU) in HIV-1 is known to be different from that of the human host. However, by reengineering the protein coding sequences of HIV-1 to reflect the RSCU patterns ...
The best sequence has an affinity of approximately 1.7 nM and seven of the isolated binders can inhibit the virus replication from 11- to 5900-fold.