The Trump administration on Friday ordered a comprehensive review of Harvard University's federally funded research programs, and threatened to take title to or grant licenses from the school's lucrative portfolio of patents.

After losing nearly $3 billion in research funding, Harvard University now risks losing control of its intellectual property in a latest Trump administration action.

The Trump administration is warning Harvard University that it could take over its patents, worth hundreds of millions of dollars, if a review finds the university hasn’t complied with federal law, an escalation of the continuing negotiations between the White House and America’s oldest university.