Recent decades have seen ever louder calls for improved study design and reproducibility standards in animal research. This stems from wider discussions across the scientific community about the ...

The development of oligonucleotide (ON) drugs such as antisense ONs and siRNAs has accelerated rapidly and is highly sought after, with increasing diversity in modalities and applications. The use of ...

Once you have determined your research question, the next step is to decide on a research design. As random assignment tends to be challenging in SoTL, most projects tend to fall into the ...

Developing treatments for rare diseases poses many unique challenges that cannot be addressed by traditional study designs. Small populations will result in prolonged enrolment periods and/or ...

Noninferiority clinical trials have become a major tool for the evaluation of drugs, devices, biologics, and other medical treatments. Treatment with placebo or with a no-treatment control in a study ...