In a recent study, FMI researchers have shed light on how intestinal organoids form crypts, the pockets that house stem cells for gut regeneration and long-term stability. Their findings may have ...

Inflammatory bowel disease (IBD) and other intestinal disorders affect millions of people worldwide, often causing lasting ...

The organoids represent one of the greatest revolutions in the biomedical field in the past decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly similar to that of ...

People who are infected with chlamydia can transmit these bacteria to other people during unprotected sex. The pathogens usually cause no symptoms, or only mild symptoms at first, such as itching in ...

Infant nutrition is crucial for early development, with breast milk regarded as the gold standard. However, replicating its nutrient absorption and metabolic outcomes in infant formula remains ...

Attrition in the therapeutic pipeline is often linked to the gap in translational efficacy between the pre-clinical phase and clinical outcomes. Organoids offer strong potential for improving disease ...

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

A team led by Prof. Dr. Dirk Haller has demonstrated for the first time that defective mitochondria cause injuries in the intestinal epithelium and influence the microbiome. In this microscopic image ...

Under the surface of an organ, many different cell types participate in crucial interactions. This means that when an organ suffers damage, fixing it is not as easy as slapping on a Band-Aid.

"Gut health" is central to maintaining overall health, but intestinal cells are susceptible to attack by oxidative stress, leading to functional disorders. However, the precise molecular mechanism ...

Researchers from the Organoid group at the Hubrecht Institute have developed a new way to grow organoids. Organoids are tiny organs that are grown in the lab and mimic the original organ. The ...