Again, for argument’s sake, if reverse transcription wasn’t a problem, mRNA would still fall at the final hurdle. As Offit explained: “Even if it were reversed transcribed to DNA, which it's ...

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

The regulation of mRNA transcription plays a key role in relaying signals from the environment and during development into the gene expression program of a cell. During transcription initiation, a ...

More information: Lior Fishman et al, Cell-type-specific mRNA transcription and degradation kinetics in zebrafish embryogenesis from metabolically labeled single-cell RNA-seq, Nature ...

Plus, the Ntensify solution works with any mRNA construct, and it is processed through one-pot in vitro transcription with co-transcriptional capping and a redesigned single-step purification to ...

Unlocking the potential of mRNA technology is helping revolutionize medicine and biotechnology. Solid-phase in vitro transcription enables scalability and automation, helping make it a valuable tool ...

One of mRNA’s greatest advantages is the ability to rapidly iterate and optimize sequences, accelerating drug discovery and development. Advances in cell-free gene synthesis and in vitro transcription ...

Genes rely on transcription factors to perform many essential functions in organs. Together, Soto-Gutiérrez and Fox have analyzed more than 400 failing livers donated by transplant patients.

During pre-mRNA transcription by Pol II, the spliceosome catalyzes two transesterification reactions along the RNA molecule, cleaving it twice and covalently joining adjacent exons, effectively ...