Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44 , 283–292 (1986) An analysis of 5'-noncoding sequences from 699 ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Additionally, it dramatically increased antibody titer by up to 128-fold in vivo, compared to the codon-optimization benchmark mRNA sequence H.

A more effective vaccine technology may be on the horizon. In a new study in mice, researchers from the University of ...

Alltrna is advancing a new class of genetic medicines based on the power of tRNA biology to universally treat Stop Codon Disease, which encompasses thousands of genetic diseases caused by a ...

mRNA display is an entire in vitro selection method that takes advantage of cell-free translation systems for the generation of polypeptide sequences. Both the expression and the selection are ...

A research team from The University of Osaka and the Institute of Science Tokyo has developed a class of mRNA medicines that ...