Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44 , 283–292 (1986) An analysis of 5'-noncoding sequences from 699 ...

Additionally, it dramatically increased antibody titer by up to 128-fold in vivo, compared to the codon-optimization benchmark mRNA sequence H.

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Ribosomes translocate along the mRNA strands one codon at a time. Codons are three nucleotide sequences in RNA that correspond to an amino acid; each codon binds to a tRNA molecule carrying the ...

Alltrna is advancing a new class of genetic medicines based on the power of tRNA biology to universally treat Stop Codon Disease, which encompasses thousands of genetic diseases caused by a ...

The team then redesigned mRNA sequences to avoid these ‘off-target’ effects, by correcting the error-prone genetic sequences in the synthetic mRNA. This produced the intended protein.” At issue is a ...

mRNA display is an entire in vitro selection method that takes advantage of cell-free translation systems for the generation of polypeptide sequences. Both the expression and the selection are ...