Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could help scientists analyze genetic data with greater ...
Alternative splicing has a crucial role in the generation of biological complexity, and its misregulation is often involved in human disease. Here we describe the assembly of a ‘splicing code’, which ...
Patterns of alternative splicing of mRNA differ between tumors and the normal tissues from which they are derived. 2 It has been recognized for some time that aberrant splicing may produce neoantigens ...
Type-II diabetes is a chronic disease caused by insulin resistance due to pancreatic β-cell dysfunction. Mutations in a single gene, HNF1A, which codes for the transcription factor hepatocyte nuclear ...
What are the mechanisms of alternative splicing? Prior to RNA splicing, RNA polymerase II produces pre-mRNA transcripts by transcribing gene sequences into a collection of non-coding introns and ...
The cover of Aging-US Volume 17, Issue 12, features Figure 5 from the research paper, titled "A combination of differential expression and network connectivity analyses identifies a common set of RNA ...
Natural killer cell transcriptomic expression and prediction of survival after immune checkpoint blockade across cancers. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This ...
BOSTON--(BUSINESS WIRE)--PepGen Inc. (Nasdaq: PEPG), a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of ...
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