New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

Accumulation of DNA damage in the brain's neurons may contribute to the development of Alzheimer's disease. New research in ...

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to discover that proteins present in the nuclear membrane of cells directly ...

A repurposed small molecule originally developed for spinal cord injury has demonstrated the ability to address multiple ...

Outcomes of nephrectomy in patients with pathologic complete response to immune checkpoint inhibitor therapy for renal cell carcinoma: A multicenter study. Sarcomatoid versus rhabdoid ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key tumor-suppressing pathways, opening up new avenues for blood cancer ...

The Fanconi anaemia pathway is a multi-component DNA damage response system devoted to the recognition and repair of DNA interstrand crosslinks (ICLs) that impede replication and transcription.

Over the past decade, researchers at WashU Medicine have established that a molecule called SARM1 is a central trigger in the loss of axons, the vital wiring of the nervous system. Axon loss is ...

A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This discovery ...