How does your body produce millions of antibodies from one genome? New research reveals how two closely related proteins help ...

Stretched into a single line, the DNA packed inside one human cell would reach roughly two meters, yet it folds into a nucleus just 5 to 10 micrometers wide. That compression ratio, on the order of ...

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

Fig. 4: The process of establishment of pre-RCs at an S. cerevisiae origin in which the B2 domain is separated from the A and B1 origin elements. This Review focuses on the first step in eukaryotic ...

The left-handed spiral of each Z-DNA strand is highlighted on the left. Binding and bonding of the two zinc finger domains (shown in red) from the CTCF protein to Z-DNA (shown in blue). This protein ...

Researchers have found that the way DNA is packaged in cells can directly impact how fast DNA itself is copied during cell division. They discovered that DNA packaging sends signals through an unusual ...

Researchers have captured the first atomic-level views of human SMUG1, a key enzyme involved in repairing damaged DNA.

The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a copy of its DNA. That's almost 120,000 base pairs per second. At that ...

Scientists have elucidated the molecular mechanism by which LEM-3 cuts DNA bridges during cytokinesis. If DNA bridges persist between chromosomes during cell division, chromosomes are abnormally ...

RNA-guided CRISPR-Cas nucleases are widely used as versatile genome-engineering tools. Among the diverse CRISPR-Cas effectors, CRISPR-Casλ—also referred to as Cas12n—is a recently identified miniature ...